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Siapas
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Name: Amber L. Colosimo
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Phone: 626-395-4887
Home  /  People  /  Athanassios G. (Thanos) Siapas

Athanassios G. (Thanos) Siapas

Professor of Computation and Neural Systems
B.S., Massachusetts Institute of Technology, 1990; M.S., 1992; Ph.D., 1996. Assistant Professor, Caltech, 2002-08; Bren Scholar 2003-08; Associate Professor, 2008-10; Professor, 2010-; Executive Officer, 2017-20.
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Research interests: network mechanisms of learning and memory, systems neuroscience, computational neuroscience, machine learning, bioengineering, neurotechnology

Overview

Our research focuses on the study of information processing across networks of neurons, with emphasis on the neuronal mechanisms that underlie learning and memory formation. By recording the simultaneous activity of large numbers of neurons in freely behaving animals, we study the structure of the interactions between the hippocampus and neocortical brain areas and the role of these interactions in learning and memory.

The hippocampus is a brain structure that has long been known to be critical for the formation of new memories. This hippocampal involvement is temporary as memories are gradually established in neocortical stores through the process of memory consolidation and their retrieval becomes independent of the hippocampus. During consolidation recently learned information is progressively integrated into cortical networks through the interactions between cortical and hippocampal circuits.

The direct experimental investigation of these interactions has been difficult since, until recently, simultaneous chronic recordings from large numbers of well-isolated single neurons were not technically feasible. These experiments became possible with the development of multi-electrode recording techniques.  Using these techniques we record the simultaneous activity of large numbers of cortical and hippocampal cells during the acquisition and performance of memory tasks, as well as during the sleep periods preceding and following experience. Our research efforts focus on analyzing the structure of cortico-hippocampal interactions in the different brain states and on characterizing how this structure is modulated by behavior; how it evolves throughout the learning process; and what it reflects about the intrinsic organization of memory processing at the level of networks of neurons. In addition, we combine two-photon imaging and whole-cell recordings in order to characterize the contributions of different neuronal cell types to circuit dynamics.

A significant focus of our current efforts also involves the development of novel technologies for monitoring and manipulating brain activity.  Our experimental work is complemented by theoretical studies of network models and the development tools for the analysis of multi-neuronal data.

Related News

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Eshan Govil Receives 2018 Henry Ford II Scholar Award
Caltech Celebrates 30 Years of its Computation and Neural Systems Option
Professor Siapas Named Vannevar Bush Faculty Fellow
Winners of the 2016 Demetriades - Tsafka - Kokkalis Prizes Announced
Charles Wang Receives 2016 Henry Ford II Scholar Award
Professor Siapas Receives NIH Pioneer Award
Athanassios Siapas and Evgueniy Lubenov Reveal the Driving Factor in the Brain's Self-regulation
Read more news   >

Publications

View more publications on feeds.library.caltech.edu

Related Courses

2022-23
CNS 100 – Introduction to Computation and Neural Systems
NB/Bi/CNS 250 c – Topics in Systems Neuroscience
2021-22
CNS 100 – Introduction to Computation and Neural Systems
NB/Bi/CNS 250 c – Topics in Systems Neuroscience
2020-21
CNS 100 – Introduction to Computation and Neural Systems
Bi/CNS/NB 250 c – Topics in Systems Neuroscience
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