News & Events

07-16-19

Leonardo da Vinci studied the motion of blood in the human body. He was interested in the heart’s passive, three-cusp aortic valve, which he realized must be operated by the motion of blood. He theorized that vortices curl back to fill the cusps in the flask-shaped constriction at the aorta’s neck. Morteza Gharib, Hans W. Liepmann Professor of Aeronautics and Bioinspired Engineering; Booth-Kresa Leadership Chair, Center for Autonomous Systems and Technologies; Director, Graduate Aerospace Laboratories; Director, Center for Autonomous Systems and Technologies, has used modern imaging techniques to demonstrate the existence of the revolving vortices that Leonardo interpreted as closing the valve. [Nature Article]

Tags: research highlights GALCIT MedE Morteza Gharib

05-16-19

Professor Lihong Wang and Postdoctoral Scholar Dr. Junhui Shi have developed a new imaging technique that uses pulses from two kinds of lasers to take pictures of microscopic biological structures. This new approach, called ultraviolet-localized mid-infrared photoacoustic microscopy, or ULM-PAM, develops images of the microscopic structures found in a piece of tissue by bombarding the sample with both infrared and ultraviolet laser light. "Because ultraviolet light and infrared have different properties, we had to find special mirrors and glass that could focus both," Dr. Shi says. "And because no camera exists that can see both, we had to develop ways to see if they were correctly focused." [Caltech story]

Tags: EE research highlights MedE Lihong Wang postdocs Junhui Shi

04-01-19

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues are using photoacoustic microscopy (PAM) to improve on an existing technology for measuring the oxygen-consumption rate (OCR). This new method allows the researchers to determine how oxygenated a sample of blood is by "listening" to the sound it makes when illuminated by the laser. Professor Wang calls this single-cell metabolic photoacoustic microscopy, or SCM-PAM. [Caltech story]

Tags: EE research highlights MedE Lihong Wang

11-13-18

Ten years ago, Caltech and City of Hope forged a partnership that combined what each institute was best at—engineering and medicine, respectively—with the goal of developing new biomedical technologies. At this year’s partnership celebration two projects were highlighted one involving Professor Yu-Chong Tai’s work on tracking tumors and the other building on Professor Morteza Gharib’s device to measure heart health. [Caltech story] [ENGenious MedE feature]

Tags: research highlights MedE Yu-Chong Tai Morteza Gharib

09-24-18

In a letter to the Caltech community during National Postdoc Appreciation Week, the Caltech President emphasizes the role this key group plays at the Institute. He stated, “Caltech's mission of world-leading research and education depends crucially on our postdoctoral scholars. Although their time at Caltech may be short, they quickly become vital parts of the Institute's intellectual fabric.” [President’s Letter] [EAS Postdoc Resource Page]

Tags: APhMS EE GALCIT MedE MCE CMS ESE Thomas Rosenbaum postdocs

08-17-18

Professor Azita Emami’s work in high-speed data communications has led to a breakthrough that could spare millions of people the need to prick themselves with needles. As she engineers a more connected world, she also is working to make it a healthier one. Professor Emami doesn’t draw a line between the different endeavors. “Electronic systems for cell phones and computers are very, very advanced,” she explains. “So why not take the knowledge we have gained developing those technologies and find ways to apply it toward solutions in medicine?” [Breakthrough story]

Tags: EE research highlights MedE Azita Emami

07-17-18

Professor Mory Gharib and postdoctoral researcher Chris Roh (MS '13, PhD '17) have studied the design and control of the jets that dragonfly larvae use to propel themselves to re-design health values. "The current heart valve design is a one-size-fits-all, where no patient-specific design is considered, and this causes many post-transplant complications," Dr. Roh says. "We believe that an intentionally off-centered opening of the heart valve to more closely match the patient's original blood flow will be an important design parameter that can be adjusted based on each patient's heart morphology." [Caltech story]

Tags: research highlights GALCIT MedE Morteza Gharib Chris Roh postdocs

07-10-18

The student winners of the 2018 Demetriades - Tsafka - Kokkalis Prizes were announced at the end of this academic year. Claire Bedbrook, advised by Professors Frances H. Arnold and Viviana Gradinaru received the prize in Biotechnology. Her research is in engineering proteins capable of controlling and reading out neural activity to advance neuroscience research. Nicholas Dou, advised by Professor Austin Minnich received the prize in Nanotechnology. Nicholas focuses on developing and characterizing novel nano-architected materials that are exceptionally lightweight, mechanically resilient, and thermally insulating. Xiaoqi Ren, advised by Professor Adam Wierman received the prize in Environmentally Benign Renewable Energy Sources. Xiaoqi’s research is focused on optimization of today's large-scale data centers, including online scheduling, energy usage and sustainability, and new market mechanisms for electricity markets and data clouds. Daniel C. Bowden, advised by Professors Joann M. Stock and Victor Tsai has received the prize in Seismo-Engineering, Prediction, and Protection. Daniel has worked on a range of projects relating to the propagation of seismic waves in the Earth's crust. Colin Cook, advised by Professor Yu-Chong Tai has receive the prize in Entrepreneurship. Colin is working on a phototherapeutic contact lens to treat diabetic retinopathy, a leading cause of blindness.

Tags: honors MedE CMS Demetriades - Tsafka - Kokkalis Prizes Xiaoqi Ren Colin Cook Claire Bedbrook Daniel Bowden Nicholas Dou

06-28-18

Azita Emami, Andrew and Peggy Cherng Professor of Electrical Engineering and Medical Engineering and Executive Officer for Electrical Engineering, Yu-Chong Tai, Anna L. Rosen Professor of Electrical Engineering and Medical Engineering; Andrew and Peggy Cherng Medical Engineering Leadership Chair; Executive Officer for Medical Engineering, and colleagues have developed a new pressure-sensing implant for the eye that could help prevent one of the leading causes of blindness. The implant could help glaucoma patients monitor their condition by wirelessly sending data about the eye to the patient or medical professionals. Patients at risk for glaucoma are required to make regular visits to an ophthalmologist to have their intraocular pressure (eye pressure) checked. The disadvantage is that patients are only able to measure pressure while visiting their doctor. With a wireless implant, a patient has access to their eye pressure data at any time, and continuous monitoring will allow intervention sooner if needed. [Caltech story]

Tags: research highlights MedE Yu-Chong Tai Azita Emami

06-18-18

A laser-sonic scanner, which uses photoacoustic computed tomography (PACT) developed by Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, can find tumors in as little as 15 seconds by shining pulses of light into the breast. The laser-sonic scanner provides a safer way for finding breast cancer compared to mammogram technology. Mammograms expose patients to X-ray radiation and requires their breasts to be painfully pressed between plates. Many women avoid having their mammograms taken as often as they should because of the discomfort involved. PACT can provide a clear view of structures as small as a quarter of a millimeter at a depth of 4 centimeters. Mammograms cannot provide soft-tissue contrast with the level of detail in PACT images. The PACT scan is quick, and a clearer image can be developed. [Caltech story]

Tags: research highlights MedE Lihong Wang