Computer Scientists Create Reprogrammable Molecular Computing System

Erik Winfree, Professor of Computer Science, Computation and Neural Systems, and Bioengineering, and colleagues have designed DNA molecules that can carry out reprogrammable computations, for the first time creating so-called algorithmic self-assembly in which the same "hardware" can be configured to run different "software." Although DNA computers have the potential to perform more complex computations than the ones featured in the Nature paper, Professor Winfree cautions that one should not expect them to start replacing the standard silicon microchip computers. That is not the point of this research. "These are rudimentary computations, but they have the power to teach us more about how simple molecular processes like self-assembly can encode information and carry out algorithms. Biology is proof that chemistry is inherently information-based and can store information that can direct algorithmic behavior at the molecular level," he says. [Caltech story]